Interactive Case Study Companion

Basal zone hyperplasia
Elongated papilla

1 - Esophagus, reflux esophagitis - Medium power  
The most common cause of esophagitis is the reflux of gastric contents; the resulting lesion is known as reflux esophagitis. Endoscopically, the esophageal mucosa may show erythema and prominent vascular markings, hemorrhage, and ulcers. Endoscopic biopsy specimens show intraepithelial eosinophils and neutrophils, basal zone hyperplasia, and elongation of lamina propria papillae. This image shows basal zone hyperplasia, characterized by a basal layer greater than 15%, and elongation of papillae that extend into the outer one third of the epithelium. The intraepithelial eosinophils and neutrophils are not evident at this magnification.  
What are the major causes of reflux esophagitis?


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